HLA Class I Allelic Sequence and Conformation Regulate Leukocyte Ig-Like Receptor Binding - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Immunology Année : 2011

HLA Class I Allelic Sequence and Conformation Regulate Leukocyte Ig-Like Receptor Binding

Résumé

Leukocyte Ig-like receptors (LILRs) are a family of innate immune receptors predominantly expressed by myeloid cells that can alter the Ag presentation properties of macrophages and dendritic cells. Several LILRs bind HLA class I. Altered LILR recognition due to HLA allelic variation could be a contributing factor in disease. We comprehensively assessed LILR binding to >90 HLA class I alleles. The inhibitory receptors LILRB1 and LILRB2 varied in their level of binding to different HLA alleles, correlating in some cases with specific amino acid motifs. LILRB2 displayed the weakest binding to HLA-B*2705, an allele genetically associated with several autoimmune conditions and delayed progression of HIV infection. We also assessed the effect of HLA class I conformation on LILR binding. LILRB1 exclusively bound folded beta(2)-microglobulin-associated class I, whereas LILRB2 bound both folded and free H chain forms. In contrast, the activating receptor LILRA1 and the soluble LILRA3 protein displayed a preference for binding to HLA-C free H chain. To our knowledge, this is the first study to identify the ligand of LILRA3. These findings support the hypothesis that LILR-mediated detection of unfolded versus folded MHC modulates immune responses during infection or inflammation. The Journal of Immunology, 2011, 186: 2990-2997.

Dates et versions

hal-01190489 , version 1 (01-09-2015)

Identifiants

Citer

Des C. Jones, Vasilis Kosmoliaptsis, Richard Apps, Nicolas Lapaque, Isobel Smith, et al.. HLA Class I Allelic Sequence and Conformation Regulate Leukocyte Ig-Like Receptor Binding. Journal of Immunology, 2011, 186 (5), pp.2990 - 2997. ⟨10.4049/jimmunol.1003078⟩. ⟨hal-01190489⟩
86 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More