Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study
Clémentine Schilte
(1)
,
Frédérik Staikovsky
(2)
,
Thérèse Couderc
(3)
,
Yoann Madec
(4)
,
Florence Carpentier
(5)
,
Somar Kassab
(6)
,
Matthew L. Albert
(1)
,
Marc Lecuit
(7, 8)
,
Alain Michault
(9)
1
Immunobiologie des Cellules Dendritiques
2 Emergency Department, Pôle des Spécialités de l'Urgence
3 Biologie des Infections - Biology of Infection
4 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology
5 BIOGER - BIOlogie et GEstion des Risques en agriculture
6 MFP - Microbiologie Fondamentale et Pathogénicité
7 Equipe avenir - Microorganismes et Barrières de l'Hôte
8 Centre d'infectiologie Necker-Pasteur [CHU Necker]
9 CHU La Réunion - Centre Hospitalier Universitaire de La Réunion
2 Emergency Department, Pôle des Spécialités de l'Urgence
3 Biologie des Infections - Biology of Infection
4 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology
5 BIOGER - BIOlogie et GEstion des Risques en agriculture
6 MFP - Microbiologie Fondamentale et Pathogénicité
7 Equipe avenir - Microorganismes et Barrières de l'Hôte
8 Centre d'infectiologie Necker-Pasteur [CHU Necker]
9 CHU La Réunion - Centre Hospitalier Universitaire de La Réunion
Thérèse Couderc
- Fonction : Auteur
- PersonId : 745715
- IdHAL : therese-couderc
- ORCID : 0000-0002-9369-0033
Yoann Madec
- Fonction : Auteur
- PersonId : 734914
- IdHAL : yoann-madec
- ORCID : 0000-0002-6201-1261
Marc Lecuit
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 943841
Connectez-vous pour contacter l'auteur
Alain Michault
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 947061
Connectez-vous pour contacter l'auteur
Résumé
BACKGROUND:
Arthritogenic alphaviruses, including Chikungunya virus (CHIKV), are responsible for acute fever and arthralgia, but can also lead to chronic symptoms. In 2006, a Chikungunya outbreak occurred in La Réunion Island, during which we constituted a prospective cohort of viremic patients (n = 180) and defined the clinical and biological features of acute infection. Individuals were followed as part of a longitudinal study to investigate in details the long-term outcome of Chikungunya.
METHODOLOGY/PRINCIPAL FINDINGS:
Patients were submitted to clinical investigations 4, 6, 14 and 36 months after presentation with acute CHIKV infection. At 36 months, 22 patients with arthralgia and 20 patients without arthralgia were randomly selected from the cohort and consented for blood sampling. During the 3 years following acute infection, 60% of patients had experienced symptoms of arthralgia, with most reporting episodic relapse and recovery periods. Long-term arthralgias were typically polyarthralgia (70%), that were usually symmetrical (90%) and highly incapacitating (77%). They were often associated with local swelling (63%), asthenia (77%) or depression (56%). The age over 35 years and the presence of arthralgia 4 months after the disease onset are risk factors of long-term arthralgia. Patients with long-term arthralgia did not display biological markers typically found in autoimmune or rheumatoid diseases. These data helped define the features of CHIKV-associated chronic arthralgia and permitted an estimation of the economic burden associated with arthralgia.
CONCLUSIONS/SIGNIFICANCE:
This study demonstrates that chronic arthralgia is a frequent complication of acute Chikungunya disease and suggests that it results from a local rather than systemic inflammation.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study
|
Résumé |
fr
BACKGROUND:
Arthritogenic alphaviruses, including Chikungunya virus (CHIKV), are responsible for acute fever and arthralgia, but can also lead to chronic symptoms. In 2006, a Chikungunya outbreak occurred in La Réunion Island, during which we constituted a prospective cohort of viremic patients (n = 180) and defined the clinical and biological features of acute infection. Individuals were followed as part of a longitudinal study to investigate in details the long-term outcome of Chikungunya.
METHODOLOGY/PRINCIPAL FINDINGS:
Patients were submitted to clinical investigations 4, 6, 14 and 36 months after presentation with acute CHIKV infection. At 36 months, 22 patients with arthralgia and 20 patients without arthralgia were randomly selected from the cohort and consented for blood sampling. During the 3 years following acute infection, 60% of patients had experienced symptoms of arthralgia, with most reporting episodic relapse and recovery periods. Long-term arthralgias were typically polyarthralgia (70%), that were usually symmetrical (90%) and highly incapacitating (77%). They were often associated with local swelling (63%), asthenia (77%) or depression (56%). The age over 35 years and the presence of arthralgia 4 months after the disease onset are risk factors of long-term arthralgia. Patients with long-term arthralgia did not display biological markers typically found in autoimmune or rheumatoid diseases. These data helped define the features of CHIKV-associated chronic arthralgia and permitted an estimation of the economic burden associated with arthralgia.
CONCLUSIONS/SIGNIFICANCE:
This study demonstrates that chronic arthralgia is a frequent complication of acute Chikungunya disease and suggests that it results from a local rather than systemic inflammation.
|
Auteur(s) |
Clémentine Schilte
1
, Frédérik Staikovsky
2
, Thérèse Couderc
3
, Yoann Madec
4
, Florence Carpentier
5
, Somar Kassab
6
, Matthew L. Albert
1
, Marc Lecuit
7, 8
, Alain Michault
9
1
Immunobiologie des Cellules Dendritiques
( 32353 )
- 25-28 rue du Docteur Roux, F-75724 Paris Cedex 15
- France
2
Emergency Department, Pôle des Spécialités de l'Urgence
( 427158 )
- France
3
Biologie des Infections - Biology of Infection
( 223010 )
- Département de Biologie cellulaire et Infection, 25-28, rue du docteur Roux, 75724 Paris Cedex 15
- France
4
Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology
( 31480 )
- Département Infection et Epidémiologie, 25-28 rue du Docteur Roux, F-75724 Paris Cedex 15
- France
5
BIOGER -
BIOlogie et GEstion des Risques en agriculture
( 89191 )
- 1 avenue Lucien Brétignières, 78850 Thiverval-Grignon
- France
6
MFP -
Microbiologie Fondamentale et Pathogénicité
( 24480 )
- Bât. 3A - 1er etg 146 Rue Léo Saignat - 103 33076 BORDEAUX CEDEX
- France
7
Equipe avenir -
Microorganismes et Barrières de l'Hôte
( 108605 )
- 28, rue du Docteur Roux 75724 Paris Cedex 15
- France
8
Centre d'infectiologie Necker-Pasteur [CHU Necker]
( 181780 )
- Service des Maladies infectieuses et Tropicales
Bâtiment Jean Hamburger
149 rue de Sèvres
75015 Paris
- France
9
CHU La Réunion -
Centre Hospitalier Universitaire de La Réunion
( 351465 )
- La Réunion
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2013-03-21
|
Licence |
Paternité
|
Nom de la revue |
|
Volume |
7
|
Langue du document |
Anglais
|
Page/Identifiant |
e2137
|
Numéro |
3
|
Localisation géographique du document |
Bioger, Bioger-Cpp, Versailles-Grignon (B 08 2013 EPIDEMIO)
|
Public visé |
Scientifique
|
Version du document |
version éditeur
|
Domaine(s) |
|
Projet(s) ANR |
|
Financement |
|
Mots-clés (Mesh) |
|
Mots-clés |
en
La Réunion, infection, epidemic, quality-of-life, reunion Island, clinical-manifestations, musculoskeletal pain, 2005-2006 outbreak, severe disease, risk-factors
|
DOI | 10.1371/journal.pntd.0002137 |
ProdINRA | 219212 |
Pubmed Id | 23556021 |
PubMed Central | PMC3605278 |
UT key WOS | 000316943800050 |
Origine :
Publication financée par une institution
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