Electrochromatography on acrylate-based monolith in cyclic olefin copolymer microchip: an attractive technology - Archive ouverte HAL Accéder directement au contenu
Chapitre D'ouvrage Année : 2015

Electrochromatography on acrylate-based monolith in cyclic olefin copolymer microchip: an attractive technology

Résumé

Electrochromatography (EC) on a porous monolithic stationary phase prepared within the channels of a microsystem is an attractive alternative for on-chip separation. It combines the separation mechanisms of electrophoresis and liquid chromatography. Moreover, the porous polymer monolithic materials have become popular as stationary phase due to the ease and rapidity of fabrication via free radical photopolymerization. Here, we describe a hexyl acrylate (HA)-based porous monolith which is simultaneously in situ synthesized and anchored to the inner walls of the channel of a cyclic olefin copolymer (COC) device in only 2 min. The baseline separation of a mixture of neurotransmitters including six amino acids and two catecholamines is realized.
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Dates et versions

hal-01187522 , version 1 (27-08-2015)

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Yoann Ladner, Gérard Crétier, Karine Faure. Electrochromatography on acrylate-based monolith in cyclic olefin copolymer microchip: an attractive technology. Van Schepdael A. (Ed). Microchip capillary electrophoresis protocols., 1274, Springer Science+Business Media, pp.161-167, 2015, Methods in molecular biology, 978-1-4939-2352-6. ⟨10.1007/978-1-4939-2353-3_14⟩. ⟨hal-01187522⟩
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