Article Dans Une Revue European Journal of Organic Chemistry Année : 2015

Copper-Mediated Synthesis of Aryldifluoromethylphosphonates: A Sandmeyer Approach

Résumé

Difluoromethylated arenes are scaffolds of great interest. We report herein a mild and general method for the introduction of the CF PO(OEt) moiety into arenes. The CuCF PO(OEt)2 species, which is generated in situ from the corresponding silylated derivatives, in combination with aryl diazonium salts furnished the highly valuable aryl difluoromethylphosphonates in moderate to good yields. This represents the first general method to introduce difluoromethylphosphonates under mild conditions.

Dates et versions

hal-01180144 , version 1 (24-07-2015)

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Citer

Alexandre Bayle, Chloé Cocaud, Cyril Nicolas, Olivier R Martin, Thomas Poisson, et al.. Copper-Mediated Synthesis of Aryldifluoromethylphosphonates: A Sandmeyer Approach. European Journal of Organic Chemistry, 2015, 2015 (17), pp.3787-3792. ⟨10.1002/ejoc.201500373⟩. ⟨hal-01180144⟩
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