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Article Dans Une Revue Theranostics Année : 2015

Nanoparticles for radiation therapy enhancement: the key parameters

Résumé

This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.

Domaines

Cancer

Dates et versions

hal-01174788 , version 1 (09-07-2015)

Identifiants

Citer

Paul Retif, Sophie Pinel, Magali Toussaint, Céline Frochot, Rima Chouikrat, et al.. Nanoparticles for radiation therapy enhancement: the key parameters. Theranostics, 2015, 5 (9), pp.1030-1044. ⟨10.7150/thno.11642⟩. ⟨hal-01174788⟩
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