This paper analyzes the distributional characteristics of demonstratives “this” and “that” so as to identify specific uses in relation to specialized domains of English. Data were collected from the ICE-GB corpus. The study consisted in extracting – oral or written – samples from sub-corpora linked to a specialized domain. The author classified the sub-corpora according to whether they corresponded to general English or to the medical, scientific and technological domains. For each sub-corpus, ICECUP was used to make queries and extract the number of occurrences of the demonstratives according to their syntactic function. Grammatical function (i.e., determiner, pro-form, adverb, complementizer or relative pronoun) was used to establish exact counts of a particular form in relation to a specific sub-corpus representing a specialized domain. The statistical results show a limited correlation between the demonstratives and the domains at a global level, but some specific functions do have a substantial link with particular specialized domains. The study reveals marked trends regarding the use of demonstratives in their pro-form function.