18F-FDG-PET/CT Imaging in Patients with Febrile Neutropenia and Haematological Malignancies. - Archive ouverte HAL
Article Dans Une Revue Anticancer Research Année : 2015

18F-FDG-PET/CT Imaging in Patients with Febrile Neutropenia and Haematological Malignancies.

Vincent Camus
Sydney Dubois

Résumé

The aim of the present study was to assess the prevalence of hyper-metabolic infection sites revealed by fluorine-18 ((18)F) fluorodeoxyglucose (FDG) positron-emission tomography (PET) combined with computed tomography (CT) in patients with febrile neutropenia (FN). Forty-eight consecutive patients with haematological malignancies and persistent FN (temperature ≥38°C and neutrophil count <500 cells/μl for more than two days) as a consequence of intensive chemotherapy were prospectively included. Pathological FDG uptakes identified 31 foci of infections located in the lungs (n=15, 48.4 %), colon (n=4, 12.9%), pancreas (n=2, 6.5%), skin (n=3, 9.7%), ear-nose-throat area (n=5, 16.1%), central venous catheter tract (n=1, 3.2%) and gallbladder (n=1, 3.2%). These pathological FDG uptakes were observed in half of the 48 patients (n=24). Among the 38 patients with a clinical diagnosis of infection, 23 showed a pathological FDG uptake, resulting in a FDG-PET/CT sensitivity of 61% (95% CI, 43-76%). Our study confirmed the ability of FDG-PET/CT to diagnose infections in patients with persistent FN.
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Dates et versions

hal-01158894 , version 1 (02-06-2015)

Identifiants

  • HAL Id : hal-01158894 , version 1
  • PUBMED : 25964587

Citer

Vincent Camus, Agathe Edet-Sanson, Michael Bubenheim, Anne Hitzel, Stéphanie Becker, et al.. 18F-FDG-PET/CT Imaging in Patients with Febrile Neutropenia and Haematological Malignancies.. Anticancer Research, 2015, 35 (5), pp.2999-3005. ⟨hal-01158894⟩
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