Journal Articles Chemistry - A European Journal Year : 2014

Electrophilic trifluoromethylthiolation of carbonyl compounds

Abstract

A general method for the α-trifluoromethylthiolation of carbonyl compounds, without prefunctionalization, has been developed. Aldehydes, ketones, esters, amides, keto-esters, alkaloids, and steroids have been trifluoromethylthiolated with good yields. This work, proposing a new reagent for electrophilic trifluoromethylthiolation, provides a route towards the original synthesis of various trifluoromethylthiolated molecules for further applications.

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Dates and versions

hal-01151171 , version 1 (12-05-2015)

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  • HAL Id : hal-01151171 , version 1

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Alazet Sébastien, Zimmer Luc, Billard Thierry. Electrophilic trifluoromethylthiolation of carbonyl compounds. Chemistry - A European Journal, 2014, 20 (28), pp.8589-8593. ⟨hal-01151171⟩
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