Rhodium-Catalyzed Cyclopropanation of Fluorinated Ole ns: A Straightforward Route to Highly Functionalized Fluorocyclopropanes - Archive ouverte HAL Access content directly
Journal Articles Organic Letters Year : 2015

Rhodium-Catalyzed Cyclopropanation of Fluorinated Ole ns: A Straightforward Route to Highly Functionalized Fluorocyclopropanes

Abstract

An efficient access to highly functionalized monofluorocyclopropanes is described. The developed methodology allowed straightforward access to a large panel of polysubstituted fluorinated cyclopropanes in good to excellent yields and good diastereoselectivities. The Rh-catalyzed cyclopropanation proved to be efficient on several fluorinated olefins and several diazo compounds. This method represents the first general route to complex fluorinated cyclopropanes.
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hal-01149632 , version 1 (07-05-2015)

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Amandine Pons, Hélène Beucher, Pavel Ivashkin, Gérald Lemonnier, Thomas Poisson, et al.. Rhodium-Catalyzed Cyclopropanation of Fluorinated Ole ns: A Straightforward Route to Highly Functionalized Fluorocyclopropanes. Organic Letters, 2015, 17 (7), pp.1790-1793. ⟨10.1021/acs.orglett.5b00576⟩. ⟨hal-01149632⟩
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