Enantioselective copper-catalyzed conjugate addition using chiral diaminocarbene ligands
Résumé
Chiral diaminocarbene ligands, generated by in-situ deprotonation of the corresponding chiral imidazolinium salts, are shown to be efficient ligands in the asymmetric copper-catalyzed 1,4-conjugate addition of diethylzinc to enones, allowing enantiomeric excesses of up to 51% to be achieved.