The objective of this paper is to present the advantages of Model reference adaptive control (MRAC) motion cueing algorithm against the classical motion cueing algorithm in terms of biome- chanical reactions of the participants during the critical maneuvers like chicane in driving simu- lator real-time. This study proposes a method and an experimental validation to analyze the ves- tibular and neuromuscular dynamics responses of the drivers with respect to the type of the con- trol used at the hexapod driving simulator. For each situation, the EMG (electromyography) data were registered from arm muscles of the drivers (flexor carpi radialis, brachioradialis). In addi- tion, the roll velocity perception thresholds (RVT) and roll velocities (RV) were computed from the real-time vestibular level measurements from the drivers via a motion-tracking sensor. In or- der to process the data of the EMG and RVT, Pearson’s correlation and a two-way ANOVA with a significance level of 0.05 were assigned. Moreover, the relationships of arm muscle power and roll velocity with vehicle CG (center of gravity) lateral displacement were analyzed in order to assess the agility/alertness level of the drivers as well as the vehicle loss of control characteristics with a confidence interval of 95%. The results showed that the MRAC algorithm avoided the loss of adhe- sion, loss of control (LOA, LOC) more reasonably compared to the classical motion cueing algo- rithm. According to our findings, the LOA avoidance decreased the neuromuscular-visual cues lev- el conflict with MRAC algorithm. It also revealed that the neuromuscular-vehicle dynamics conflict has influence on visuo-vestibular conflict; however, the visuo-vestibular cue conflict does not in- fluence the neuromuscular-vehicle dynamics interactions.