Ligand-Free Pd-Catalyzed and Copper-Assisted C−H Arylation ofQuinazolin-4-ones with Aryl Iodides under Microwave Heating
Résumé
A microwave-assisted method for the palladiumcatalyzeddirect arylation of quinazolin-4-one has beendeveloped under copper-assistance. This method is applicableto a wide range of aryl iodides and substituted (2H)-quinazolin-4-ones. This protocol provides a simple and efficient way tosynthesize biologically relevant 2-arylquinazolin-4-one backbones.