ULPC-MS/MS phenolic quantification and in vitro anticancer potential of Gmelina arborea Roxb. (Verbenaceae)
Résumé
Phenolic secondary metabolites are recognized as excellent antioxidants and are subject of numerous scientific
studies. The present study was aimed firstly, to quantify the phenolic constituents contained in the hydroacetonic
crude extract obtained from Gmelina arborea leaves by UPLC-MS/MS and secondly, to investigate in vitro its
anticancer potential against 6 cancerous cell lines. The quantitative analysis revealed a significant abundance in
flavonoids (75.50%) and a presence of hydroxycinnamic acid derivatives (24.49%). The results of cytotoxicity
survey clearly indicate that the hydroacetonic crude extract shows a good anticancer activity against C6 glioma
cells.