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Article Dans Une Revue (Article De Synthèse) Systems Biology in Reproductive Medicine Année : 2012

The contribution of proteomics to understanding epididymal maturation of mammalian spermatozoa

Résumé

The acquisition of the ability of the male gamete to fertilize an ovum is the result of numerous and sequential steps of differentiation of spermatozoa that occur as they transit from the testis to the end of the epididymal tubule. The post gonadal sperm modifications are mostly related to motility, egg binding, and penetration processes. As the activity of the epididymis and its luminal fluid composition are believed to bedirectly related to sperm maturation, a review on epididymal proteins is presented. Comparative studies have shown that the epididymal activities are species specific. Nevertheless, for all mammalian species studied, similarities exist in the sequential proteomic changes of the luminal composition of the epididymal tubule and proteins on the sperm surface. The potential roles of these modifications are discussed.

Domaines

Autre [q-bio.OT]

Dates et versions

hal-01129631 , version 1 (10-03-2015)

Identifiants

Citer

Jean-Louis Dacheux, Clémence Belleannée, Benoit Guyonnet, Valérie Labas, Ana-Paula Teixeira-Mechin, et al.. The contribution of proteomics to understanding epididymal maturation of mammalian spermatozoa. Systems Biology in Reproductive Medicine, 2012, 58 (4), pp.197-210. ⟨10.3109/19396368.2012.663233⟩. ⟨hal-01129631⟩
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