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Article Dans Une Revue Nucleic Acids Research Année : 2011

PhyleasProg: a user-oriented web server for wide evolutionary analyses

Résumé

Evolutionary analyses of biological data are becoming a prerequisite in many fields of biology. At a time of high-throughput data analysis, phylogenetics is often a necessary complementary tool for biologists to understand, compare and identify the functions of sequences. But available bioinformatics tools are frequently not easy for non-specialists to use. We developed PhyleasProg (http://phyleasprog.inra.fr), a user-friendly web server as a turnkey tool dedicated to evolutionary analyses. PhyleasProg can help biologists with little experience in evolutionary methodologies by analysing their data in a simple and robust way, using methods corresponding to robust standards. Via a very intuitive web interface, users only need to enter a list of Ensembl protein IDs and a list of species as inputs. After dynamic computations, users have access to phylogenetic trees, positive/purifying selection data (on site and branch-site models), with a display of these results on the protein sequence and on a 3D structure model, and the synteny environment of related genes. This connection between different domains of phylogenetics opens the way to new biological analyses for the discovery of the function and structure of proteins.

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Dates et versions

hal-01129520 , version 1 (29-05-2020)

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Paternité - Pas d'utilisation commerciale

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Joël Busset, Cédric Cabau, Camille Meslin, Géraldine Pascal. PhyleasProg: a user-oriented web server for wide evolutionary analyses. Nucleic Acids Research, 2011, 39 (Web Server issue), pp.W479-W485. ⟨10.1093/nar/gkr243⟩. ⟨hal-01129520⟩
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