In the past decade, Runtime Verification (RV) has gained much focus, from both the research community and practitioners. RV combines a set of theories, techniques and tools aiming towards efficient analysis of systems' executions and guaranteeing their correctness using monitoring techniques. Major challenges in RV include characterizing and formally expressing requirements that can be monitored, offering intuitive and concise specification formalisms, and monitoring specifications efficiently for functional and non-functional behavior. In spite of the major strides made in recent years, much effort is still needed to make RV an attractive and viable methodology for industrial use and to apply it to wider application domains, such as security, bio-health, power micro-grids. This special issue of STTT proposes extended versions of four papers that have been selected from the Runtime Verification track at ISoLA 2012 [10].