Efficient radio resource management and Quality ofService (QoS) guarantee are very important aspects in order toprovide a good service in LTE Networks. Although the base stationperforms a smart scheduling scheme for resource allocation,the expected result could be affected due to interference, speciallyin femtocell scenarios. This article investigates the problem ofinterference in femtocell networks in LTE. The proposed methodachieves inter-cell interference mitigation though a dynamicpower self-control performed at each femtocell. In this paperwe use the modulation and coding scheme (MCS) to obtain theoptimum power value which assures a trade-off between Signalto-Interference-plus-Noise-Ratio (SINR) and bit-rate efficiency.The main objective of our work is to optimize the sub-bands inorder to decrease the interference and maintain the throughputat the same time. The performance evaluation is conducted interms of throughput, Packet Loss Ratio (PLR) and SINR.