The estimation of the seismic vulnerability of buildings at an urban scale, a crucial element in any risk assessment, is an expensive, time-consuming, and complicated task, especially in moderate-to-low seismic hazard regions, where the mobilization of resources for the seismic evaluation is reduced, even if the hazard is not negligible. In this paper, we propose a way to perform a quick estimation using convenient, reliable building data that are readily available regionally instead of the information usually required by traditional methods. Using a dataset of existing buildings in Grenoble (France) with an EMS98 vulnerability classification and by means of two different data mining techniques—association rule learning and support vector machine—we developed seismic vulnerability proxies. These were applied to the whole France using basic information from national databases (census information) and data derived from the processing of satellite images and aerial photographs to produce a nationwide vulnerability map. This macroscale method to assess vulnerability is easily applicable in case of a paucity of information regarding the structural characteristics and constructional details of the building stock. The approach was validated with data acquired for the city of Nice, by comparison with the RiskUE method. Finally, damage estimations were compared with historic earthquakes that caused moderate-to-strong damage in France. We show that due to the evolution of vulnerability in cities, the number of seriously damaged buildings can be expected to double or triple if these historic earthquakes were to occur today.