Multifunctional material based on ionic transition metal complexes and gold–silica nanoparticles: Synthesis and photophysical characterization for application in imaging and therapy - Archive ouverte HAL Access content directly
Journal Articles Journal of Photochemistry and Photobiology B: Biology Year : 2014

Multifunctional material based on ionic transition metal complexes and gold–silica nanoparticles: Synthesis and photophysical characterization for application in imaging and therapy

Abstract

A new combination of luminescent ionic transition-metal complexes (M = Ru(II) or Ir(III)) with gold silica-based nanoparticles (GSNPs) gives a promising nanomaterial for application in biomedical fields. Herein we report the synthesis and the photophysical properties of Ru(II) and Ir(III) complexes doped gold core-polysiloxane shell particles prepared by microemulsion method and characterized by Transmission Electron Microscopy, Dynamic Light Scattering and UV–Vis spectroscopy. The cytotoxicity and photodynamic activity of the obtained 50 nm-diameter nanoparticles were evaluated in vitro, providing noteworthy results. Furthermore, their intrinsic phosphorescence allows the localization of the photosensitizing nanoparticles into the cytosol of tumor cells by fluorescence confocal microscope. These valuable features designate them as multifunctional nanoplatforms for theranostic purposes.

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Imaging Cancer
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Dates and versions

hal-01115693 , version 1 (11-02-2015)

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Loredana Ricciardi, Matteo Martini, Olivier Tillement, Lucie Sancey, Pascal Perriat, et al.. Multifunctional material based on ionic transition metal complexes and gold–silica nanoparticles: Synthesis and photophysical characterization for application in imaging and therapy. Journal of Photochemistry and Photobiology B: Biology, 2014, 140, pp.396-404. ⟨10.1016/j.jphotobiol.2014.09.005⟩. ⟨hal-01115693⟩
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