Radiation dose enhancement of gadolinium-based AGuIX nanoparticles on HeLa cells - Archive ouverte HAL Access content directly
Journal Articles Nanomedicine: Nanotechnology, Biology and Medicine Year : 2014

Radiation dose enhancement of gadolinium-based AGuIX nanoparticles on HeLa cells

Abstract

Radiation dose enhancement of high-Z nanoparticles is an active area of research in cancer therapeutics. When kV and MV energy photon beams interact with high-Z nanoparticles in a tumor, the release of secondary electrons can injure tumor cells, leading to a higher treatment efficacy than radiation alone. We present a study that characterizes the radiation dose enhancing effects of gadolinium-based AGuIX nanoparticles on HeLa cells. Our in vitro clonogenic survival assays showed an average dose enhancement of 1.54× for 220 kVp radiation and 1.15× for 6 MV radiation. The sensitivity enhancement ratio at 4 Gy (SER4Gy) was 1.54 for 220 kVp and 1.28 for 6 MV, indicating that these nanoparticles may be useful for clinical radiation therapy.

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Cancer
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hal-01115659 , version 1 (11-02-2015)

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Matthew Luchette, Houari Korideck, Mike Makrigiorgos, Olivier Tillement, Ross Berbeco. Radiation dose enhancement of gadolinium-based AGuIX nanoparticles on HeLa cells. Nanomedicine: Nanotechnology, Biology and Medicine, 2014, 10 (8), pp.1751-1755. ⟨10.1016/j.nano.2014.06.004⟩. ⟨hal-01115659⟩
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