A finite elements method to solve the Bloch–Torrey equation applied to diffusion magnetic resonance imaging
Résumé
The complex transverse water proton magnetization subject to diffusion-encoding magnetic
field gradient pulses in a heterogeneous medium can be modeled by the
multiple compartment Bloch-Torrey partial differential equation (PDE).
In addition, steady-state Laplace PDEs can be formulated to produce the
homogenized diffusion tensor that describes the diffusion characteristics
of the medium in the long time limit.
In spatial domains that model biological tissues at the cellular level, these two
types of PDEs have to be completed with permeability conditions on the cellular interfaces.
To solve these PDEs, we implemented a finite elements method that
allows jumps in the solution at the cell interfaces by using double
nodes. Using a transformation of the Bloch-Torrey PDE we reduced oscillations
in the searched-for solution and simplified the implementation
of the boundary conditions. The spatial discretization
was then coupled to the adaptive explict Runge-Kutta-Chebychev time-stepping method.
Our proposed method is second order accurate in space and second order accurate in time.
We implemented this method on the FEniCS
C++ platform and show time and spatial convergence results.
Finally, this method is applied to study some relevant questions in diffusion
MRI.
Domaines
Modélisation et simulationOrigine | Fichiers produits par l'(les) auteur(s) |
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