In this paper, the problem of increasing reliability of active control procedure is considered. Indeed, a design method of rejection perturbation in presence of potentially faults, on a flexible structure with integrated piezo-ceramics, is presented. The piezo-ceramics are used as actuators and sensors. A single unit based solution, which handles both control action and fault diagnosis is proposed. The algorithm uses H∞ optimization techniques. A full order model of the structure is first obtained via both finite-element (FE) approach and identification procedure. This model is then reduced in order to be used in our robust approach. By a suitable choice of weightings functions, the provided method is able to reject disturbance robustly and to estimate occurred faults. The case of sensors and actuators faults is discussed. The choice of weightings for diagnosis and control systems is also tackled. Finally, the effectiveness of this integrated method is confirmed by both simulation and experimental results.