The evolution of metazoan α-carbonic anhydrases and their roles in calcium carbonate biomineralization. - Archive ouverte HAL Access content directly
Journal Articles (Review Article) Frontiers in Zoology Year : 2014

The evolution of metazoan α-carbonic anhydrases and their roles in calcium carbonate biomineralization.

Abstract

The carbonic anhydrase (CA; EC 4.2.1.1) superfamily is a class of ubiquitous metallo-enzymes that catalyse the reversible hydration of carbon dioxide. The α-CA family, present in all metazoan clades, is a key enzyme involved in a wide range of physiological functions including pH regulation, respiration, photosynthesis, and biocalcification. This paper reviews the evolution of the α-CA family, with an emphasis on metazoan α-CA members involved in biocalcification. Phylogenetic analyses reveal a complex evolutionary history of α-CAs, and suggest α-CA was independently co-opted into a variety of skeleton forming roles (e.g. as a provider of HCO3− ions, a structural protein, a nucleation activator, etc.) in multiple metazoan lineages. This evolutionary history is most likely the result of multiple gene duplications coupled with the insertion of repetitive or non-repetitive low-complexity domains (RLCDs/LCDs). These domains, of largely unknown function, appear to be lineage-specific, and provide further support for the hypothesis of independent recruitment of α-CAs to diverse metazoan biocalcification processes. An analysis of α-CA sequences associated with biocalcification processes indicates that the domains involved in the activity and conformation of the active site are extremely conserved among metazoans.
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hal-01100241 , version 1 (12-02-2024)

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Nathalie Le Roy, Daniel J. Jackson, Benjamin Marie, Paula Ramos-Silva, Frédéric Marin. The evolution of metazoan α-carbonic anhydrases and their roles in calcium carbonate biomineralization.. Frontiers in Zoology, 2014, 11, pp.75. ⟨10.1186/s12983-014-0075-8⟩. ⟨hal-01100241⟩
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