The growing of ageing population worldwide and the need to concentrate research efforts on a specific target group motivate our research to focus on frail ageing persons with chronic disease and physical/cognitive deficiencies. The primary goal is to enable frail and dependant persons, through reliable assistive technologies, to maximize their physical and mental functions, and to continue to engage in social networks, so that he can continue to lead an independent and purposeful life. Our target is to analyse the users in their own home through an extensive survey performed in France recently and to design the suitable assistive system, which is mainly composed of devices available on the market. This research activity lead to the deployment of a simplified hardware infrastructure (gateway, sensors, actuators) in the home of end-users with a limited number of wireless sensors and to the outsourcing of all the software for data analysis in a distant server. The research focuses on the quality of life of ageing people having cognitive and functional limitations, and on recent achievements realised in France and Singapore through several European and national projects, and through Quality of Life Chair (QoL) directed by Mounir Mokhtari and supported by two major health insurance companies in France Mutuelle Generale and REUNICA.