Synthesis and Characterization of Hydroxyapatite Ceramics Organofunctionalized with ATP (Adenosine Triphosphate) - Archive ouverte HAL Access content directly
Journal Articles Journal of Advances in Chemistry Year : 2014

Synthesis and Characterization of Hydroxyapatite Ceramics Organofunctionalized with ATP (Adenosine Triphosphate)

Abstract

Adenosine triphosphate (ATP) is the main source of energy for cells. In this article we investigated, with a possible future finality in bone tissue engineering, the original association of ATP molecules and hydroxyapatite (HAp) fine powders. We have in particular inspected, in a preliminary way, the effects of the presence of ATP molecules on the physico-chemistry of apatite compounds obtained via co-precipitation. Hybrids were produced by association of increasing amounts of adenosine 5’-triphosphate (ATP) disodium hydrate salt with hydroxyapatite, leading to so-called “organoapatites”. The structure and composition of the polycrystalline hybrid compounds obtained were studied by XRD, FTIR, SEM and magic angle spinning (MAS) NMR techniques. The presence of ATP was found to alter the apatite crystallization process, leading to a departure from stoichiometry. MAS-NMR data attest to the presence of strong interactions between functional groups of ATP and apatite particles unveiling the obtainment of class II hybrids with potential future applications in cell-loaded bone scaffolds.
Fichier principal
Vignette du fichier
Hammami_12055.pdf (1.08 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-01092592 , version 1 (09-12-2014)

Identifiers

  • HAL Id : hal-01092592 , version 1

Cite

Khaled Hammami, Jihene Elloumi, Sami Aifa, Christophe Drouet, Hafed El Feki. Synthesis and Characterization of Hydroxyapatite Ceramics Organofunctionalized with ATP (Adenosine Triphosphate). Journal of Advances in Chemistry, 2014, vol. 9 (n° 1), pp. 1787-1797. ⟨hal-01092592⟩
381 View
290 Download

Share

Gmail Facebook X LinkedIn More