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Article Dans Une Revue Chemistry - A European Journal Année : 2014

Silaproline Helical Mimetics Selectively Form an All-trans PPII Helix

Résumé

The polyproline II helix (PPII) is increasingly recognized as an important element in peptide and protein structures. The discovery of pertinent PPII peptidomimetics is of great interest to tune physical properties of the targeted structure. A series of silaproline oligomers from dimer to pentamer were synthesized. CD studies, NMR spectroscopy and molecular modeling revealed that the ribbon preferentially populates the polyproline type II secondary structure in both [D]chloroform and [D4]MeOH. The characteristics of this new lipophilic PPII-like helix were determined.

Domaines

Chimie organique

Dates et versions

hal-01078148 , version 1 (28-10-2014)

Identifiants

Citer

Charlotte Martin, Baptiste Legrand, Aurélien Lebrun, Dorothée Berthomieu, Jean Martinez, et al.. Silaproline Helical Mimetics Selectively Form an All-trans PPII Helix. Chemistry - A European Journal, 2014, 20 (44), pp.1420-14244. ⟨10.1002/chem.201404820⟩. ⟨hal-01078148⟩
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