An Introduction to Drug Discovery by Probing Protein-Substrate Interactions Using Saturation Transfer Difference-Nuclear Magnetic Resonance (STD-NMR). - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Chemical Education Année : 2012

An Introduction to Drug Discovery by Probing Protein-Substrate Interactions Using Saturation Transfer Difference-Nuclear Magnetic Resonance (STD-NMR).

Résumé

NMR spectroscopy is a powerful tool for characterizing and identifying mols. and nowadays is even used to characterize complex systems in biol. In the expt. presented here, students learned how to apply this modern technique to probe interactions between small mols. and proteins. With the use of simple org. synthesis, students prepd. different analogs of the well-known anxiolytic drug, nitrazepam. This study constituted the students' first approach into the drug-discovery field and encouraged the students to think about how to improve the design of drugs in a rational way. [on SciFinder(R)]

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hal-01070111 , version 1 (30-09-2014)

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Jean-Paul Guégan, Richard Daniellou. An Introduction to Drug Discovery by Probing Protein-Substrate Interactions Using Saturation Transfer Difference-Nuclear Magnetic Resonance (STD-NMR).. Journal of Chemical Education, 2012, 89, pp.1071--1073. ⟨10.1021/ed100612k⟩. ⟨hal-01070111⟩
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