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Article Dans Une Revue Journal of Physical Chemistry B Année : 2014

From Nucleobases to Nucleolipids: An ITC Approach on the Thermodynamics of Their Interactions in Aqueous Solutions

Résumé

Hybrid constructions based on nucleosides and lipophilic components, known as nucleolipids, have become an extremely interesting class of molecules, especially for their potential biomedical applications. In this matter, it seemed important to define the nature and estimate the strength of their interaction with polynucleotides by different ways. We report in this work a systematic investigation through isothermal titration calorimetry of the thermodynamics of the association and dissociation of adenine and thymine derivatives, not previously performed....
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Dates et versions

hal-01069673 , version 1 (29-09-2014)

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Angelos Thanassoulas, Philippe Barthélémy, Laurence Navailles, Gilles Sigaud. From Nucleobases to Nucleolipids: An ITC Approach on the Thermodynamics of Their Interactions in Aqueous Solutions. Journal of Physical Chemistry B, 2014, 118 (24), pp. 6570-6585. ⟨10.1021/jp411459w⟩. ⟨hal-01069673⟩

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