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Journal Articles Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences (1934–1990) Year : 2015

Incompressible limit of mechanical model of tumor growth with viscosity

Abstract

Various models of tumor growth are available in the litterature. A first class describes the evolution of the cell number density when considered as a continuous visco-elastic material with growth. A second class, describes the tumor as a set and rules for the free boundary are given related to the classical Hele-Shaw model of fluid dynamics. Following the lines of previous papers where the material is described by a purely elastic material, or when active cell motion is included, we make the link between the two levels of description considering the 'stiff pressure law' limit. Even though viscosity is a regularizing effect, new mathematical difficulties arise in the visco-elastic case because estimates on the pressure field are weaker and do not imply immediately compactness. For instance, traveling wave solutions and numerical simulations show that the pressure may be discontinous in space which is not the case for the elastic case.
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Dates and versions

hal-01066494 , version 1 (20-09-2014)

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Benoît Perthame, Nicolas Vauchelet. Incompressible limit of mechanical model of tumor growth with viscosity. Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences (1934–1990), 2015, 373, pp.20140283. ⟨10.1098/rsta.2014.0283⟩. ⟨hal-01066494⟩
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