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Article Dans Une Revue Trends in Pharmacological Sciences Année : 2014

Targeting of Smoothened for therapeutic gain.

Résumé

The Smoothened (Smo) receptor is a key transducer of the Hedgehog (Hh) signaling pathway, which plays a critical role in tissue maintenance and repair. Recent studies have highlighted the therapeutic value of Smo antagonists for treating Hh-linked cancers. Research on Smo agonists indicates that these molecules are important not only for delineating canonical versus noncanonical Hh signaling but also for understanding the role of Smo in physiological and pathological conditions. This review provides an update on the potential therapeutic importance of Smo modulators, and unravels the increasing complexity of its pharmacology with regard to clinical implications.
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Dates et versions

hal-01055292 , version 1 (12-08-2014)

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Martial Ruat, Lucile Hoch, Hélène Faure, Didier Rognan. Targeting of Smoothened for therapeutic gain.. Trends in Pharmacological Sciences, 2014, 35 (5), pp.237-46. ⟨10.1016/j.tips.2014.03.002⟩. ⟨hal-01055292⟩
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