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Article Dans Une Revue Inhalation Toxicology Année : 2014

Toxicity of boehmite nanoparticles: impact of the ultrafine fraction and of the agglomerates size on cytotoxicity and pro-inflammatory response

Mohamed Sennour

Résumé

Boehmite (γ-AlOOH) nanoparticles (NPs) are used in a wide range of industrial applications. However, little is known about their potential toxicity. This study aimed at a better understanding of the relationship between the physico-chemical properties of these NPs and their in vitro biological activity. After an extensive physico-chemical characterization, the cytotoxicity, pro-inflammatory response and oxidative stress induced by a bulk industrial powder and its ultrafine fraction were assessed using RAW264.7 macrophages. Although the bulk powder did not trigger a significant biological activity, pro-inflammatory response was highly enhanced with the ultrafine fraction. This observation was confirmed with boehmite NPs synthesized at the laboratory scale, with well-defined and tightly controlled physico-chemical features: toxicity was increased when NPs were dispersed. In conclusion, the agglomerates size of boehmite NPs has a major impact on their toxicity, highlighting the need to study not only raw industrial powders containing NPs but also the ultrafine fractions representative of respirable particles. Read More: http://informahealthcare.com/doi/abs/10.3109/08958378.2014.925993
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Dates et versions

hal-01020274 , version 1 (19-09-2014)

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Valérie Forest, Mélanie Pailleux, Jérémie Pourchez, Delphine Boudard, Maura Tomatis, et al.. Toxicity of boehmite nanoparticles: impact of the ultrafine fraction and of the agglomerates size on cytotoxicity and pro-inflammatory response. Inhalation Toxicology, 2014, 26 (9), pp.545-553. ⟨10.3109/08958378.2014.925993⟩. ⟨hal-01020274⟩
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