Reduction with tris(2-carboxyethyl)phosphine (TCEP) enables the use of an S-sulphonate protecting group for thiol-mediated bioconjugation. - Archive ouverte HAL
Article Dans Une Revue RSC Advances Année : 2014

Reduction with tris(2-carboxyethyl)phosphine (TCEP) enables the use of an S-sulphonate protecting group for thiol-mediated bioconjugation.

Résumé

Herein, we demonstrate the effectiveness of the water-friendly S-sulphonate group as an alternative to traditional thiol protecting groups for subsequent deprotection-bioconjugation reactions, under conditions that are compatible with the use of biochemical samples.

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Chimie organique

Patrice Heritier  : Connectez-vous pour contacter le contributeur

https://hal.science/hal-01005376

Soumis le : jeudi 12 juin 2014-14:45:28

Dernière modification le : mardi 16 avril 2024-16:16:05

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Dates et versions

hal-01005376 , version 1 (12-06-2014)

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Citer

Barbara Maret, Thomas Régnier, Jean-Christophe Rossi, Laurent Garrelly, Laurent Vial, et al.. Reduction with tris(2-carboxyethyl)phosphine (TCEP) enables the use of an S-sulphonate protecting group for thiol-mediated bioconjugation.. RSC Advances, 2014, 4 (15), pp.7725-728. ⟨10.1039/c3ra47407k⟩. ⟨hal-01005376⟩

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