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Communication Dans Un Congrès Année : 2011

How PI-3-P mediates entry of oomycete, fungal and insect effectors into host cells

B. M. B. M. Tyler
  • Fonction : Auteur
S. D. S. D. Kale
  • Fonction : Auteur
V. V. Antignani
  • Fonction : Auteur
J. J. Vega-Arreguin
  • Fonction : Auteur
R. R. Anderson
  • Fonction : Auteur
B. B. Gu
  • Fonction : Auteur
D. G. D. G. Capelluto
  • Fonction : Auteur
D. D. Dou
  • Fonction : Auteur
E. E. Feldman
  • Fonction : Auteur
A. A. Rumore
  • Fonction : Auteur
F. D. F. D. Arredondo
  • Fonction : Auteur
R. R. Hanlon
  • Fonction : Auteur
R.R. Aggarwal
  • Fonction : Auteur
Francis Martin
  • Fonction : Auteur
  • PersonId : 1203179
J. J. J. J. Stuart
  • Fonction : Auteur
J. M. J. M. Mcdowell
  • Fonction : Auteur
C. B. C. B. Lawrence
  • Fonction : Auteur
W. W. Shan
  • Fonction : Auteur

Résumé

Symbionts, both pathogenic and beneficial, must integrate their physiology with that of their host in order to achieve a successful colonization. Effector proteins that enter the cytoplasm of host cells are widely utilized for this purpose by bacterial, fungal, oomycete, protistan, nematode, and insect symbionts. The soybean pathogen Phytophthora sojae, one of the best characterized oomycete pathogens, encodes in its genome nearly 400 potential effector proteins with the cell-entry motif RXLR. We have recently identified the mechanism by which effector proteins from pathogens and mutualists from two different kingdoms of life, Fungi and Oomycetes, enter the cells of their plant hosts. The mechanism involves the previously undetected presence of the phospholipid phosphatidylinositol-3-phosphate (PI-3-P) on the outer surface of the plasma membrane of plant cells. The virulence proteins utilize PI-3-P as a receptor to gain entry via lipid-raft mediated endocytosis. More recently, we have discovered that two diverse insect pests of plants (hessian flies and aphids) also produce proteins that can bind PI-3-P via RXLR motifs in order to enter plant cells, where they suppress host defenses while the insects feed. We are current exploring methodologies for disrupting PI-3-P-mediated effector entry in order to create new means for managing oomycete and fungal diseases and insect pests.
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Dates et versions

hal-01001505 , version 1 (04-06-2014)

Identifiants

  • HAL Id : hal-01001505 , version 1
  • PRODINRA : 207446
  • WOS : 000295045401759

Citer

B. M. B. M. Tyler, S. D. S. D. Kale, V. V. Antignani, J. J. Vega-Arreguin, R. R. Anderson, et al.. How PI-3-P mediates entry of oomycete, fungal and insect effectors into host cells. APS-IPPC Joint Meeting, Aug 2011, Honolulu, Hawaii, United States. pp.230. ⟨hal-01001505⟩
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