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Article Dans Une Revue Developmental and Comparative Immunology Année : 2011

Early antiviral response and virus-induced genes in fish

Résumé

In fish as in mammals, virus infections induce changes in the expression of many host genes. Studies conducted during the last fifteen years revealed a major contribution of the interferon system in fish antiviral response. This review describes the screening methods applied to compare the impact of virus infections on the transcriptome in different fish species. These approaches identified a "core" set of genes that are strongly induced in most viral infections. The "core" interferon-induced genes (ISGs) are generally conserved in vertebrates, some of them inhibiting a wide range of viruses in mammals. A selection of ISGs - PKR, vig-1/viperin, Mx, ISG15 and finTRIMs - is further analyzed here to illustrate the diversity and complexity of the mechanisms involved in establishing an antiviral state. Most of the ISG-based pathways remain to be directly determined in fish. Fish ISGs are often duplicated and the functional specialization of multigenic families will be of particular interest for future studies.

Domaines

Immunologie

Dates et versions

hal-01000200 , version 1 (04-06-2014)

Identifiants

Citer

Eloi E. Verrier, Christelle C. Langevin, Abdenour A. Benmansour, Pierre Boudinot. Early antiviral response and virus-induced genes in fish. Developmental and Comparative Immunology, 2011, 35 (12), pp.1204-1214. ⟨10.1016/j.dci.2011.03.012⟩. ⟨hal-01000200⟩
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