Inverse Peptide Synthesis via Activated α-Aminoesters - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Angewandte Chemie International Edition Année : 2014

Inverse Peptide Synthesis via Activated α-Aminoesters

Résumé

A mild, practical, and simple procedure for peptide-bond formation is reported. Instead of activation of the carboxylic acid functionality, the reaction involves an unprecedented use of activated α-aminoesters. The method provides a straightforward entry to dipeptides and was effective when a sensitive cysteine residue was used, as no epimerization was detected in this case. The applicability of this method to iterative peptide synthesis was illustrated by the synthesis of a model tetrapeptide in the challenging reverse N→C direction.

Dates et versions

hal-00992960 , version 1 (19-05-2014)

Identifiants

Citer

Jean-Simon Suppo, Gilles Subra, Matthieu Berges, Renata Marcia de Figueiredo, Jean-Marc Campagne. Inverse Peptide Synthesis via Activated α-Aminoesters. Angewandte Chemie International Edition, 2014, 53 (21), pp.5389-5393. ⟨10.1002/anie.201402147⟩. ⟨hal-00992960⟩
176 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More