Integrative sol-gel chemistry based strategies allow, through the strong coupling between materials chemistry and advanced processing, the fabrication of functional inorganic and hybrid materials. The following article will highlight some of the main accomplishments performed during the last years in the design of nano- and multi-scale structured materials shaped as thin films, powders and monoliths with additional functionalities and outstanding properties in several fields of application such as optics, catalysis and nanomedicine. In particular we discuss the key role played by the adapted liquid processing of sol- gel based solution. We will describe some technologies (including dip coating, spray drying, droplet-microfluidics, ink-jet and foaming) in which a high degree of control in term of liquid shaping/evaporation/manipulation is required in order to achieve specific functionalities.