Purkinje cells and Bergmann glia are primary targets of the TRα1 thyroid hormone receptor during mouse cerebellum postnatal development. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Development (Cambridge, England) Année : 2014

Purkinje cells and Bergmann glia are primary targets of the TRα1 thyroid hormone receptor during mouse cerebellum postnatal development.

Teddy Fauquier
  • Fonction : Auteur
Fabrice Chatonnet
Frédéric Picou
Sabine Richard
Nicolas Fossat
  • Fonction : Auteur
Nadine Aguilera
  • Fonction : Auteur
Frederic Flamant

Résumé

Thyroid hormone is necessary for normal development of the central nervous system, as shown by the severe mental retardation syndrome affecting hypothyroid patients with low levels of active thyroid hormone. The postnatal defects observed in hypothyroid mouse cerebellum are recapitulated in mice heterozygous for a dominant-negative mutation of Thra, the gene encoding the ubiquitous TRα1 receptor. Using CRE/loxP-mediated conditional expression approach, we found that this mutation primarily alters the differentiation of Purkinje cells and Bergmann glia, two cerebellum-specific cell types. These primary defects indirectly affect cerebellum development in a global manner. Notably, the inward migration and terminal differentiation of granule cell precursors is impaired. Therefore, despite the broad distribution of its receptors, thyroid hormone targets few cell types that exert a predominant role in the network of cellular interactions that govern normal cerebellum maturation.

Dates et versions

hal-00968730 , version 1 (01-04-2014)

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Citer

Teddy Fauquier, Fabrice Chatonnet, Frédéric Picou, Sabine Richard, Nicolas Fossat, et al.. Purkinje cells and Bergmann glia are primary targets of the TRα1 thyroid hormone receptor during mouse cerebellum postnatal development.. Development (Cambridge, England), 2014, 141 (1), pp.166-75. ⟨10.1242/dev.103226⟩. ⟨hal-00968730⟩
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