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Article Dans Une Revue Médecine/Sciences Année : 2013

[Reprogramming pancreatic cells to β cells].

Résumé

Type 1 diabetes (T1DM) is a common metabolic disorder affecting an ever-increasing number of patients worldwide. T1DM is caused by the selective destruction of pancreatic insulin-producing β-cells by the immune system. Such loss results in chronic hyperglycemia and could induce a number of cardio-vascular complications. Despite the classical insulin-based therapy, compared to healthy people, patients with T1DM display a shortened life expectancy due to the treatment's inability to strictly regulate glycemic levels. An alternative therapy involves pancreatic islet transplantation but the shortage of donors and the required immuno-suppressive treatments limit the widespread use of this approach. Therefore, the search of new approaches to generate functional β-cells is of growing interest. In this review, we describe several novel strategies aiming at the conversion of diverse pancreatic cells into β-cells, such as acinar, ductal, and endocrine cells. Clearly, such promising results could open new research avenues in the context of type 1 diabetes research.

Dates et versions

hal-00968710 , version 1 (01-04-2014)

Identifiants

Citer

Andhira Vieira, Noémie Druelle, Monica Courtney, Fabio Avolio, Nouha Ben-Othman, et al.. [Reprogramming pancreatic cells to β cells].. Médecine/Sciences, 2013, 29 (8-9), pp.749-55. ⟨10.1051/medsci/2013298014⟩. ⟨hal-00968710⟩
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