An extension of the non local (NL) means is proposed for images damaged by Poisson noise. The proposed method is guided by the noisy image and a pre-filtered image and is adapted to the statistics of Poisson noise. The influence of both images can be tuned using two filtering parameters. We propose an automatic setting to select these parameters based on the minimization of the estimated risk (mean square error). This selection uses an estimator of the MSE for NL means with Poisson noise and Newton's method to find the optimal parameters in few iterations.