We report a new depolarization sensing modality (DSOB), based on the concept of polarization orthogonality breaking, enabling direct measurement of a polarimetric contrast from a single measurement. The principle of this technique is described, as well as its benefits (compatibility with remote sensing through fibers, spectral agility…). Experimental validation of this technique on a fibred setup is extensively described and confirms its appropriateness for remote sensing through optical fibers. We eventually present the first DSOB images obtained in the visible range on a confocal microscope setup. The acquisition times reported are encouraging for future implementation in real-time.