Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria. - Archive ouverte HAL Access content directly
Journal Articles Nature Communications Year : 2013

Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria.

Damien Le Roy
Nora M. Dempsey

Abstract

The modulation of developmental biochemical pathways by mechanical cues is an emerging feature of animal development, but its evolutionary origins have not been explored. Here we show that a common mechanosensitive pathway involving β-catenin specifies early mesodermal identity at gastrulation in zebrafish and Drosophila. Mechanical strains developed by zebrafish epiboly and Drosophila mesoderm invagination trigger the phosphorylation of β-catenin-tyrosine-667. This leads to the release of β-catenin into the cytoplasm and nucleus, where it triggers and maintains, respectively, the expression of zebrafish brachyury orthologue notail and of Drosophila Twist, both crucial transcription factors for early mesoderm identity. The role of the β-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila. This suggests mesoderm mechanical induction dating back to at least the last bilaterian common ancestor more than 570 million years ago, the period during which mesoderm is thought to have emerged.

Dates and versions

hal-00951438 , version 1 (24-02-2014)

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Thibaut Brunet, Adrien Bouclet, Padra Ahmadi, Démosthène Mitrossilis, Benjamin Driquez, et al.. Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria.. Nature Communications, 2013, 4, pp.2821. ⟨10.1038/ncomms3821⟩. ⟨hal-00951438⟩
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