Copper-catalyzed oxidative three-component synthesis of N, N',N″-trisubstituted guanidines. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Organic Letters Année : 2013

Copper-catalyzed oxidative three-component synthesis of N, N',N″-trisubstituted guanidines.

Résumé

A copper-catalyzed three-component synthesis of trisubstituted N-aryl guanidines involving cyanamides, arylboronic acids, and amines has been developed. This operationally simple oxidative process, which is performed in the presence of K2CO3, a catalytic amount of CuCl2*2H2O, bipyridine, and oxygen (1 atm), allows the rapid assembly of N,N',N″-trisubstituted aryl guanidines.

Domaines

Chimie organique
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Dates et versions

hal-00949344 , version 1 (19-02-2014)

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Jihui Li, Luc Neuville. Copper-catalyzed oxidative three-component synthesis of N, N',N″-trisubstituted guanidines.. Organic Letters, 2013, 15 (24), pp.6124-7. ⟨10.1021/ol4029622⟩. ⟨hal-00949344⟩
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