A method for evaluating the absorption and transmission performances of multi-layer micro-perforated structures whose facings are excited by different noise sources is described here. It is applied to determine if the acoustical performances of a number of Micro-Perforated Panels (MPPs), optimised both in absorption and transmission, exceed those of typical aircraft panels undergoing internal and external acoustic excitations. A fully-coupled modal formulation is presented that accounts for the effects of the sub-structure volumetric resonances on the acoustical properties of the partitions. It is validated against full-scale measurements performed with a pressure-velocity probe and a laser vibrometer to estimate the absorption and transmission coefficients of single- and double-layer micro-perforated partitions. The model is used to optimise the sound power dissipated by three layouts obtained from a typical aircraft partition by micro-perforating the trim panel (MPP-Porous-Panel), removing the fibreglass material (MPP-Cavity-Panel) and adding a second MPP inside the separating cavity (MPP- MPP-Panel). It is concluded that the MPP-Porous-Panel and MPP-MPP-Panel layouts provide excess interior noise reduction above 1.8 kHz and 1.2 kHz respectively, whereas the MPP-Cavity-Panel is not acoustically more efficient than a typical aircraft panel.