Article Dans Une Revue Phytochemistry Letters Année : 2013

Anti-AGEs and antiparasitic activity of an original prenylated isoflavonoid and flavanones isolated from Derris ferruginea

Résumé

A new isoflavonoid, 5-hydroxy-3-(4-hydroxyphenyl)-8-isopropenyl-8,9-dihydro-4H-furo-[2,3-h]-chromen-4-one named derrisisoflavone G (1), four known prenylated flavanones (2–5), four known isoflavonoids (6–9) and two phenolic derivatives (10, 11) have been isolated from crude extracts of Derris ferruginea stems and leaves. Compounds 1–11 were identified using spectroscopic methods whereas an unambiguous structural assignment of 1 was accomplished through hemi-synthesis. Compounds 2–5 exhibited strong in vitro antiparasitic activity against Plasmodium falciparum and Leishmania major but with poor selectivity, whereas 1–5 significantly inhibited the formation of advanced glycation endproducts (AGEs).

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hal-00911058 , version 1 (13-09-2023)

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Sylvie Morel, Jean-Jacques Helesbeux, Denis Séraphin, Séverine Derbré, Julia Gatto, et al.. Anti-AGEs and antiparasitic activity of an original prenylated isoflavonoid and flavanones isolated from Derris ferruginea. Phytochemistry Letters, 2013, 6 (3), pp.498-503. ⟨10.1016/j.phytol.2013.06.002⟩. ⟨hal-00911058⟩
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