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Communication Dans Un Congrès Année : 2011

3D Simulation of an in vitro Epithelial to Mesenchymal Transition.

Résumé

A 3D simulation of in vitro epithelial to mesenchymal transition (EMT) is presented. The simulation uses Compucell3D to realize a cellular Potts model of this process. The purpose of the model is to test the hypothesis that EMT can be achieved through a combination of a) the loss of endocardial cohesion; and b) a gain of endocardial to extracellular matrix adhesion. The results of the simulation demonstrate confirmation of the hypothesis. A mechanism by which EMT could be regulated by mitosis is demonstrated. Further, the implication of the study to heart development is explored.

Dates et versions

hal-00908869 , version 1 (25-11-2013)

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Ron Summers, Tariq Abdulla, R. A. Imms, Jean-Marc Schleich. 3D Simulation of an in vitro Epithelial to Mesenchymal Transition.. 5th European Conference of the International Federation for Medical and Biological Engineering, Sep 2011, Budapest, Hungary. pp.1287-1290, ⟨10.1007/978-3-642-23508-5_333⟩. ⟨hal-00908869⟩
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