The existence of the quantum vacuum is well established in the Standard Model of Particles and Fields but completely neglected in contemporary Astrophysics and Cosmology. It is a major and absolutely urgent task to reveal if and how quantum vacuum contributes to the gravitational field of baryonic matter in the Universe. We point out that a first signature of the gravitational impact of the quantum vacuum might be seen in the perihelion precession of orbits of satellites of minor planets in outer part of the Solar System. As an example we consider the minor planet 2002 UX25 and its satellite.