Tuning molecular interactions in lipid-oligonucleotides assemblies via locked nucleic acid (LNA)-based lipids - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2013

Tuning molecular interactions in lipid-oligonucleotides assemblies via locked nucleic acid (LNA)-based lipids

Résumé

Hybrid nucleotide-lipids containing locked nucleic acid (LNA) show enhanced hybridization properties with complementary single strand RNAs compared to DNA lipid analogues. The LNA adenosine lipid features unique binding properties with a high binding affinity for poly-uridine and the entropically driven formation of a stable complex (Kd ≈ 43 nM). Enhanced hybridization properties of LNA-based lipids should be applicable for the development of oligonucleotide (ON) delivery systems or as small molecule binders to RNA for novel therapeutic strategies.
Fichier non déposé

Dates et versions

hal-00903600 , version 1 (12-11-2013)

Identifiants

Citer

Amit Patwa, Gilmar Salgado, François Dole, Laurence Navailles, Philippe Barthélémy. Tuning molecular interactions in lipid-oligonucleotides assemblies via locked nucleic acid (LNA)-based lipids. Organic & Biomolecular Chemistry, 2013, 11, pp. 7108-7112. ⟨10.1039/c3ob41707g⟩. ⟨hal-00903600⟩

Collections

CNRS CRPP INC-CNRS
39 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More