The mouse model is suitable for the study of viral factors governing transmission and pathogenesis of highly pathogenic avian influenza (HPAI) viruses in mammals - Archive ouverte HAL Access content directly
Journal Articles Veterinary Research Year : 2010

The mouse model is suitable for the study of viral factors governing transmission and pathogenesis of highly pathogenic avian influenza (HPAI) viruses in mammals

Michela Rigoni
  • Function : Author
Anna Toffan
  • Function : Author
Elisabetta Viale
  • Function : Author
Marzia Mancin
  • Function : Author
Filippo Cilloni
  • Function : Author
Elena Bertoli
  • Function : Author
Angela Salomoni
  • Function : Author
Sabrina Marciano
  • Function : Author
Adelaide Milani
  • Function : Author
Bianca Zecchin
  • Function : Author
Ilaria Capua
  • Function : Author
Giovanni Cattoli
  • Function : Author

Abstract

Highly pathogenic avian influenza (HPAI) viruses of the H5 and H7 subtype pose a major public health threat due to their capacity to cross the species barrier and infect mammals, for example dogs, cats and humans. In the present study we tested the capacity of selected H7 and H5 HPAI viruses to infect and to be transmitted from infected BALB/c mice to contact sentinels. Previous experiments have shown that viruses belonging to both H5 and H7 subtypes replicate in the respiratory tract and central nervous system of experimentally infected mice. In this study we show that selected H7N1 and H5N1 HPAI viruses can be transmitted from mouse-to-mouse by direct contact, and that in experimentally infected animals they exhibit a different pattern of replication and transmission. Our results can be considered as a starting point for transmission experiments involving other influenza A viruses with α 2-3 receptor affinity in order to better understand the viral factors influencing transmissibility of these viruses in selected mammalian species.
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hal-00903193 , version 1 (11-05-2020)

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Michela Rigoni, Anna Toffan, Elisabetta Viale, Marzia Mancin, Filippo Cilloni, et al.. The mouse model is suitable for the study of viral factors governing transmission and pathogenesis of highly pathogenic avian influenza (HPAI) viruses in mammals. Veterinary Research, 2010, 41 (5), ⟨10.1051/vetres/2010038⟩. ⟨hal-00903193⟩
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