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Article Dans Une Revue Genetics Selection Evolution Année : 2004

Genetic analysis of a divergent selection for resistance to Rous sarcomas in chickens

Marie-Hélène Pinard-van Der Laan
Denis Soubieux
  • Fonction : Auteur
Laurence Mérat
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Danièle Bouret
  • Fonction : Auteur
Gillette Luneau
  • Fonction : Auteur
Ginette Dambrine
  • Fonction : Auteur
Pierrick Thoraval
  • Fonction : Auteur

Résumé

Selection for disease resistance related traits is a tool of choice for evidencing and exploring genetic variability and studying underlying resistance mechanisms. In this framework, chickens originating from a base population, homozygote for the $B^{19}$ major histocompatibility complex (MHC) were divergently selected for either progression or regression of tumors induced at 4 weeks of age by a SR-D strain of Rous sarcoma virus (RSV). The first generation of selection was based on a progeny test and subsequent selections were performed on full-sibs. Data of 18 generations including a total of 2010 birds measured were analyzed for the tumor profile index (TPI), a synthetic criterion of resistance derived from recording the volume of the tumors and mortality. Response to selection and heritability of TPI were estimated using a restricted maximum likelihood method with an animal model. Significant progress was shown in both directions: the lines differing significantly for TPI and mortality becoming null in the "regressor" line. Heritability of TPI was estimated as 0.49 $\pm $ 0.05 and 0.53 $\pm $ 0.06 within the progressor and regressor lines respectively, and 0.46 $\pm $ 0.03 when estimated over lines. Preliminary results showed within the progressor line a possible association between one Rfp-Y type and the growth of tumors.

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hal-00894474 , version 1 (11-05-2020)

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Marie-Hélène Pinard-van Der Laan, Denis Soubieux, Laurence Mérat, Danièle Bouret, Gillette Luneau, et al.. Genetic analysis of a divergent selection for resistance to Rous sarcomas in chickens. Genetics Selection Evolution, 2004, 36 (1), pp.65-81. ⟨10.1051/gse:2003051⟩. ⟨hal-00894474⟩
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