Methods of sonification based on the design and control of sound synthesis is presented in this paper. The semiotics of isolated sounds was evidenced by per- forming fundamental studies using a combined acoustical and brain imaging (event-related potentials) approach. The perceptual cues (which are known as invariants) responsi- ble for the evocations elicited by the sounds generated by impacts, moving sound sources, dynamic events and vehicles (car-door closing and car engine noise) were then identified based on physical and perceptual considerations. Lastly, some examples of the high-level control of a syn- thesis process simulating immersive 3-D auditory scenes, interacting objects and evoked dynamics are presented.